Anti-Wrinkle
Dermal Fillers
Amorim
PRP Therapy
Exosome Treatment
iS Clinical Facials
Microneedling
Fat Dissolving
Polynucleotides
Lumi Eyes
Vampire Facial
Fat Dissolving
Nucleofill Strong is a high-concentration polynucleotide (PDRN) injectable — a biomaterial derived from purified salmon DNA that has been clinically validated across decades of regenerative medicine research. It doesn’t work by adding volume or hydration on top of your skin. It works by changing the behaviour of the cells beneath it.
When injected, PDRN activates A2A adenosine receptors on your skin cells — triggering a cascade of repair and regeneration signals that increase collagen and elastin synthesis, accelerate the turnover of damaged cells, reduce inflammation, and improve microvascular circulation in the treated area. The result is skin that doesn’t just look healthier. It structurally is healthier, at a cellular level, from the inside out.
“Nucleofill Strong is the treatment I reach for when I want genuinely deep, structural skin improvement not just surface enhancement. The cellular mechanism is in a different league.”
The “Strong” formulation is Nucleofill’s most concentrated product — designed for clients with significant skin quality concerns, visible ageing, or those seeking the maximum regenerative effect. It requires a course to achieve full biological impact, and the results continue to develop for weeks after each session as the tissue remodelling process completes.
PDRN molecules bind to A2A adenosine receptors on fibroblasts, triggering the cellular signalling pathway that initiates collagen and elastin synthesis — the biological foundation of skin firmness and elasticity.
Polynucleotide chains are broken down into nucleotides that enter the cell's DNA salvage pathway providing the raw building blocks for cellular repair and replication in damaged tissue.
Nucleofill reduces pro-inflammatory cytokines in treated tissue calming chronic low-grade skin inflammation that accelerates ageing, and creating an environment where healthy regeneration can occur.
PDRN promotes the formation of new microvascular networks, improving blood flow and nutrient delivery to treated skin restoring the kind of healthy circulation that gives skin its natural glow and vitality.
Unlike treatments with an immediate but finite effect, Nucleofill results accumulate across a course each session building on the last, with tissue quality continuing to improve for weeks after treatment ends.
Nucleofill Strong is appropriate for a wide range of skin concerns but it’s particularly powerful for those seeking deep, structural improvement rather than cosmetic surface enhancement.
Rough, uneven skin texture — the kind that doesn't respond to topical skincare no matter how diligently it's applied — is often the result of structural changes beneath the surface. Nucleofill addresses these from within, producing measurable improvements in skin smoothness, tone and overall quality across a course of sessions.
By stimulating genuine new collagen and elastin production not just temporarily filling over them Nucleofill Strong addresses the underlying cause of fine lines and skin laxity. Results develop over weeks as new structural proteins are synthesised, producing a firmer, denser skin quality that persists long after the treatment itself.
The under-eye area is one of the most requested treatment sites for Nucleofill and one of the most responsive. The anti-inflammatory and microcirculation-improving effects specifically address the vascular component of dark circles, while the collagen stimulation improves the thin, crepey skin quality that makes the area appear hollow and aged.
Nucleofill's PDRN activates the same hyaluronic acid production mechanisms that decline with age but instead of injecting HA externally, it stimulates your own cells to produce it. This biologically native hydration integrates naturally with your tissue and creates a lasting improvement in skin moisture and plumpness that external fillers cannot replicate.
