Advanced Regeneration

Polynucleo­tides

Restore. Rebuild. Renew.

Polynucleotides fragments of purified DNA penetrate deep into the dermis activating fibroblasts and switching on the skin’s own regeneration pathways from within.

Anti-Wrinkle

Dermal Fillers

Amorim

PRP Therapy

Exosome Treatment

iS Clinical Facials

Microneedling

Fat Dissolving

Polynucleotides

Lumi Eyes

Vampire Facial

Fat Dissolving

— The Science

What Are Polynucleotides?

Polynucleotides commonly known by the active compound PDRN (Polydeoxyribonucleotide) are fragments of purified, highly biocompatible DNA derived from salmon or trout sperm. Before that raises any eyebrows the genetic material is so thoroughly processed and purified that the final product is simply a chain of nucleotide building blocks the same fundamental units that make up human DNA.

When injected into the skin these nucleotide chains are recognised by the body as repair signals. They bind to specific receptors on fibroblast cells triggering a cascade of regenerative activity: increased collagen and elastin synthesis enhanced hyaluronic acid production, and accelerated healing at a cellular level.

What makes polynucleotides uniquely remarkable is their ability to address the architecture of the skin itself not just its surface. They improve the quality and density of the extracellular matrix the invisible scaffolding that gives skin its firmness resilience and youthful structure. This is why results feel so genuine because they fundamentally are.

Victor has seen polynucleotide therapy transform skin that had stopped responding to conventional treatments. Used alone or as part of a wider regenerative protocol the results are consistent progressive and deeply rewarding for both practitioner and client.

Stimulates Collagen & Elastin

PDRN directly activates fibroblasts your skin's structural repair cells promoting the production of new collagen and elastin to restore firmness and bounce.

Targets the Under-Eye Zone

One of the most effective treatments available for the periorbital area visibly improving dark circles, hollowness, crepiness, and fine lines around the eyes without filler.

Improves Skin Hydration & Glow

Polynucleotides significantly boost the skin's own hyaluronic acid production delivering deep, lasting hydration and a luminosity that topical products cannot replicate.

Anti-Inflammatory & Healing

Strongly anti-inflammatory by nature ideal for post-acne skin, rosacea, and reactive or sensitised skin types that have not responded well to other aesthetic treatments.

Ideal For

Under-Eye Concerns
Ageing Skin
Loss of Firmness

Post-Acne

Dull Complexion

— Before & After

Clear Skin. Real People.

Every photograph is from a genuine Amorim Clinic client taken before their first peel and at a follow-up appointment after completing their course. All results are shared with full written consent. Outcomes will vary depending on skin type, lifestyle and the treatment programme followed.
— FAQ

Frequently Asked Questions

Polynucleotides are still relatively new in the UK aesthetic market so we understand there are questions. Here are the ones Victor hears most often.

Still have questions?

Victor will assess your skin, explain exactly which peel is right for you, and answer any questions without obligation or pressure.

Are polynucleotides the same as fillers or skin boosters?
No polynucleotides are fundamentally different. Dermal fillers add volume by physically filling space (typically with hyaluronic acid) while skin boosters hydrate and plump the surface. Polynucleotides do neither of these things directly instead they work at a biological level stimulating your skin’s own cells to produce collagen, elastin and hyaluronic acid. The results take longer to appear but are entirely your own skin’s creation which is why they feel and look so natural.
The small raised wheals or bumps visible immediately after polynucleotide injections are entirely normal and expected they are simply the product sitting in the superficial dermis before being absorbed. They are not an allergic reaction. In most cases they resolve within 4–24 hours. The under-eye area can occasionally show more visible bumping due to the thinness of the skin in that zone this too resolves on its own and is not a cause for concern. Victor will explain exactly what to expect before you leave.
Polynucleotides are a biostimulator they work by triggering a biological process rather than producing an immediate volumising effect. Most clients notice improved hydration and a subtle glow within the first 1–2 weeks. The deeper results improved texture, firmness, and reduction of fine lines build progressively over 4–8 weeks as new collagen is synthesised. This is why a course of 3 sessions is so effective each session builds on the last and results continue to improve even after the course is complete.
With prescription topical anaesthesia applied beforehand, most clients find the treatment comfortable describing it as a mild pricking sensation rather than pain. The under-eye area is naturally more sensitive but numbing cream significantly reduces discomfort. In terms of downtime, most clients return to normal activities the same day. You may have small bumps and mild redness for up to 24 hours so we recommend not scheduling the treatment the day before an important event. Makeup can typically be worn the following morning.
Mesotherapy is a broad term for microinjections of a cocktail of vitamins minerals and amino acids essentially delivering nutrients directly to the dermis. It improves hydration and glow. Polynucleotides are a specific single active ingredient (PDRN) with a precise mechanism of action they bind to receptors on fibroblasts and directly activate collagen synthesis and tissue repair. They are more targeted more clinically studied, and produce more substantial structural changes than a standard mesotherapy cocktail.
Treatment Options

Choose Your Regenerative Path

Skin Repair & Under-Eye Rejuvenation

£195

1 session

  • Face & Neck £320

Skin Repair & Under-Eye Rejuvenation

£900

Course of 6

  • Face & Neck £320

Skin Repair & Under-Eye Rejuvenation

£480

Course of 3

  • Face & Neck £320
— The Experience

What to Expect

Every polynucleotide session at Amorim Clinic is performed with the same unhurried care and clinical precision. You’ll never feel rushed and you’ll always leave knowing exactly what was done and what to expect next.

Ready to Book Your Consultation?

Book a complimentary consultation with Victor and find out whether polynucleotide therapy is the right treatment for your skin. Honest advice. No pressure. Just results.